Potential in vitro inhibitory effects of Moringa oleifera leaf extracts on extended-spectrum β-lactamase-producing bacteria

Extended-spectrum β-lactamase (ESβL) enzymes are produced by certain bacteria as a mechanism of resistance to β-lactam and extended-spectrumβ-lactam antibiotics. Previous investigations have confirmed that M. oleifera contains several bioactive compounds. This study aimed at evaluating the in vitro antibacterial effects ethanolic methanolic leaf extracts on extended-spectrum producing bacteria. The plant were prepared, screened for compounds evaluated inhibitory against ESβL-producing using agar well diffusion method. Different phytochemicals detected from extracts. Both showed high activity, which increased with an increase concentration, lowest highest based zones growth inhibition produced. Amongst test organisms, Klebsiella pneumoniae was most sensitive isolate extract 200, 100, 50 25mg/mL followed Escherichia coli, then Proteus mirabilis. However, terms extract, same concentrations those methanol extracts, E. coli found be K. P.